Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3132253 | 0.91 | SSTR5 (0.44) | ALDH1A1SSTR5PKMMAPK1GLA | |
| SCHEMBL3094321 | 0.89 | L3MBTL1 (0.57) | ALDH1A1SSTR5PKMMAPK1GLA | |
| SCHEMBL3138202 | 0.89 | ALDH1A1 (0.48) | ALDH1A1PKMMAPK1GLAUBE2N | |
| SCHEMBL3130955 | 0.87 | SSTR5 (0.47) | ALDH1A1SSTR5PKMMAPK1GLA | |
| SCHEMBL3130713 | 0.87 | ALDH1A1 (0.48) | ALDH1A1SSTR5PKMMAPK1GLA | |
| SCHEMBL3132297 | 0.85 | MAPK1 (0.51) | ALDH1A1SSTR5MAPK1UBE2NNPSR1 | |
| SCHEMBL3134424 | 0.83 | OPRM1 (0.53) | SMN1; SMN2 | |
| SCHEMBL3138408 | 0.81 | USP2 (0.43) | ALDH1A1SSTR5PKMMAPK1GLA | |
| SCHEMBL3130702 | 0.81 | USP2 (0.42) | ALDH1A1SSTR5PKMMAPK1GLA | |
| SCHEMBL3128667 | 0.81 | SSTR5 (0.48) | ALDH1A1SSTR5PKMMAPK1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | claimed |