Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 9/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29264345 | 0.73 | DDB1 (0.47) | DDB1CRBNTP53TNKSMEN1 | |
| SCHEMBL31385992 | 0.71 | DDB1 (0.37) | DDB1CRBNTNKSMAPT | |
| SCHEMBL29225363 | 0.70 | DDB1 (0.51) | DDB1CRBNMEN1KMT2AHPGD | |
| SCHEMBL23120751 | 0.70 | DDB1 (0.52) | DDB1CRBNMEN1KMT2AHPGD | |
| SCHEMBL29223732 | 0.66 | PDK4 (0.46) | DDB1CRBNPDK4 | |
| SCHEMBL24607496 | 0.65 | PDK4 (0.52) | DDB1CRBNPDK4 | |
| SCHEMBL26683865 | 0.64 | DDB1 (0.41) | DDB1CRBNTP53TNKSHPGD | |
| SCHEMBL31623036 | 0.64 | CRBN (0.55) | DDB1CRBNTNKS | |
| SCHEMBL19284621 | 0.64 | MAPT (0.47) | TP53MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL31623011 | 0.64 | CRBN (0.51) | DDB1CRBNTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727591-A1 | SMARCA2 DEGRADERS AND USES THEREOF | Astrazeneca AB (SE) | 2026-04-22 | — | — | EP | disclosed |
| WO-2024256988-A1 | SMARCA2 DEGRADERS AND USES THEREOF | ASTRAZENECA AB (SE) | 2024-12-19 | — | — | WO | disclosed |