SCHEMBL31391663

SCHEMBL31391663

Fc1cc(F)cc(C(COCc2ccccc2)c2cccc(F)c2Br)c1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 10/20 0.39
HSP90AA1 P07900 1/20 0.36
SLC6A9 P48067 1/20 0.36
SLC6A5 Q9Y345 1/20 0.36
CA1 P00915 4/20 0.35
CA2 P00918 2/20 0.35
CA7 P43166 2/20 0.35
CA9 Q16790 2/20 0.35
TSHR P16473 1/20 0.35
MEN1 O00255 1/20 0.35
TP53 P04637 1/20 0.35
GAA P10253 1/20 0.35
KMT2A Q03164 1/20 0.35
SLC1A1 P43005 1/20 0.34
CACNA1F O60840 1/20 0.33
CACNA1D Q01668 1/20 0.33
CACNA1S Q13698 1/20 0.33
CACNA1C Q13936 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23901101 0.78 TACR1 (0.39) TACR1CA1CA2CA7CA9
SCHEMBL28999529 0.70 TACR1 (0.37) TACR1CA1CA2CA7CA9
SCHEMBL22785928 0.67 CA1 (0.47) TACR1SLC6A9SLC6A5CA1CA2
SCHEMBL23901095 0.65 JAK2 (0.41) TACR1GAA
SCHEMBL2113201 0.64 MAPT (0.55)
SCHEMBL30674557 0.64 MAPT (0.55)
SCHEMBL13131317 0.61 TSHR (0.61) TACR1CA1CA2CA7CA9
SCHEMBL4540283 0.61 KDM1A (0.56)
SCHEMBL22785865 0.61 CA1 (0.47) TACR1CA1CA2CA7CA9
SCHEMBL13361125 0.61 MAN2A1 (0.48) TACR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115916771-B Multi-target antitumor compound and preparation method and application thereof 浙江华海药业股份有限公司 2025-04-01 CN disclosed