Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31396136 | 0.85 | ACHE (0.43) | KDM4ENPSR1POLBMAPTALDH1A1 | |
| SCHEMBL18320638 | 0.76 | POLB (0.43) | KDM4ENPSR1POLBL3MBTL1TDP1 | |
| SCHEMBL16759802 | 0.75 | TSHR (0.44) | KDM4EPOLBL3MBTL1MAPTALDH1A1 | |
| SCHEMBL12072208 | 0.74 | RXFP1 (0.48) | KDM4ENPSR1POLBL3MBTL1TDP1 | |
| SCHEMBL20723122 | 0.73 | KDM4E (0.45) | KDM4ENPSR1POLBL3MBTL1TDP1 | |
| SCHEMBL18320768 | 0.69 | KDM4E (0.40) | KDM4ENPSR1POLBL3MBTL1TDP1 | |
| SCHEMBL18328058 | 0.67 | KDM4E (0.39) | KDM4ENPSR1POLBL3MBTL1TDP1 | |
| SCHEMBL31396038 | 0.67 | ACHE (0.48) | KDM4EPOLBMAPTALDH1A1GAA | |
| SCHEMBL18320808 | 0.66 | POLB (0.40) | KDM4EPOLBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL28035983 | 0.66 | ALOX15 (0.56) | KDM4EALDH1A1TSHRPRNPRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739684-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008060-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |