Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25C | P30307 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1338440 | 0.81 | MAP2 (0.45) | MAP2NOTUMPOLBPTPN11JAK2 | |
| SCHEMBL1338074 | 0.70 | L3MBTL1 (0.40) | MAP2NOTUMPOLBPTPN11PIM1 | |
| SCHEMBL1338048 | 0.63 | NOTUM (0.38) | NOTUMCNR1CNR2 | |
| SCHEMBL1338675 | 0.62 | CNR1 (0.37) | CHEK1CNR1CNR2 | |
| SCHEMBL482367 | 0.62 | POLB (1.00) | NOTUMPOLBPTPN11PIM1HPGDS | |
| SCHEMBL1771547 | 0.62 | LMNA (0.69) | — | |
| SCHEMBL1816589 | 0.61 | NOTUM (1.00) | NOTUMPOLBPTPN11JAK2PIM1 | |
| SCHEMBL1338159 | 0.60 | POLB (0.45) | MAP2NOTUMPOLBPTPN11JAK2 | |
| SCHEMBL6049622 | 0.59 | TYMS (0.44) | GUSB | |
| SCHEMBL1770784 | 0.59 | GRIN2D (0.38) | PIM1CNR1CNR2GUSBCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |