Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 18/20 | 0.79 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.79 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.79 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.79 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.79 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.79 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.79 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.79 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17088099 | 0.91 | GABRG2 (0.82) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL2845754 | 0.89 | GABRG2 (0.80) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL638718 | 0.88 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL8273440 | 0.85 | GABRG2 (0.73) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL14574154 | 0.85 | GABRG2 (0.79) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL2851649 | 0.85 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL16062590 | 0.84 | GABRG2 (0.72) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL2841060 | 0.83 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL2848785 | 0.83 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL2849597 | 0.83 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004226-A1 | STEREOSPECIFIC ANXIOLYTIC AND ANTICONVULSANT AGENTS WITH REDUCED MUSCLE-RELAXANT, SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS | COOK JAMES M | 2010-01-07 | — | — | US | disclosed |
| US-20100004226-A1 | STEREOSPECIFIC ANXIOLYTIC AND ANTICONVULSANT AGENTS WITH REDUCED MUSCLE-RELAXANT, SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS | COOK JAMES M | 2010-01-07 | — | — | US | disclosed |
| US-7618958-B2 | Convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnosis; Ethyl 8-bromo-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618958-B2 | Convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnosis; Ethyl 8-bromo-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20060003995-A1 | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060003995-A1 | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects | GABRE, GABRA6, GABRA5 | GABRG2 21/4885GABRB3 14/4885GABRA5 3/4885 |
| US-20100004226-A1 | STEREOSPECIFIC ANXIOLYTIC AND ANTICONVULSANT AGENTS WITH REDUCED MUSCLE-RELAXANT, SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS | CHRNA6, GABRA6, CHRNA5 | GABRG2 24/4885GABRB3 17/4885GABRA5 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.