Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17016669 | 0.71 | PDPK1 (0.55) | PDPK1KDM5BRAB9A | |
| SCHEMBL30719412 | 0.69 | ACVR1 (0.41) | ACVR1PDPK1KDM5BAKT1AKT2 | |
| SCHEMBL21193333 | 0.66 | KCNH2 (0.41) | KDM5BAKT1AKT2ALDH1A1LRRK2 | |
| SCHEMBL23739421 | 0.66 | ACVR1 (0.55) | ACVR1PDPK1AKT1AKT2CDC7 | |
| SCHEMBL8404474 | 0.65 | — | — | |
| SCHEMBL20180773 | 0.65 | PDPK1 (0.43) | PDPK1ALDH1A1KDM4ELMNAPIM1 | |
| SCHEMBL17151214 | 0.65 | PDPK1 (0.44) | ACVR1PDPK1AKT1AKT2CDK2 | |
| SCHEMBL26242523 | 0.65 | KCNH2 (0.40) | KDM5BAKT1AKT2CDC7CCNE1 | |
| Hydrochloric Acid SCHEMBL30557166 | 0.64 | ACVR1 (0.54) | ACVR1PDPK1AKT1AKT2CDC7 | |
| SCHEMBL3740850 | 0.63 | AKT2 (0.70) | ACVR1AKT1AKT2KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270198-A1 | PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS | D. E. SHAW RESEARCH, LLC | 2025-08-28 | — | — | US | disclosed |
| CN-119451948-A | Pyridone compounds as TRPA1 inhibitors | D·E·萧尔研究有限责任公司 | 2025-02-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250270198-A1 | PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV6 | ACVR1 2073/4885PDPK1 1249/4885KDM5B 2144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.