Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.49 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 6/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30608796 | 0.76 | AKT1 (0.46) | AURKAAURKBINCENPTPX2FYN | |
| SCHEMBL3301267 | 0.73 | BACE1 (0.41) | AURKAAURKBLRRK2ROCK1PRKACA | |
| SCHEMBL22736242 | 0.72 | AURKA (0.51) | AURKAAURKBINCENPTPX2FYN | |
| SCHEMBL30063761 | 0.71 | AKT2 (0.45) | AURKAAURKBINCENPTPX2FYN | |
| SCHEMBL30291111 | 0.69 | AKT1 (0.41) | AURKAAURKBINCENPTPX2AKT2 | |
| SCHEMBL19028096 | 0.69 | AKT1 (0.46) | AURKAAURKBINCENPTPX2FYN | |
| SCHEMBL29490387 | 0.67 | AKT1 (0.42) | AURKAAURKBINCENPTPX2FYN | |
| SCHEMBL23276953 | 0.67 | IDO1 (0.57) | AURKAAURKBINCENPTPX2AKT2 | |
| SCHEMBL30961311 | 0.67 | AKT1 (0.38) | AURKAAURKBINCENPTPX2FYN | |
| SCHEMBL38651397 | 0.67 | MAPK1 (0.37) | AURKAAURKBINCENPTPX2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270198-A1 | PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS | D. E. SHAW RESEARCH, LLC | 2025-08-28 | — | — | US | disclosed |
| CN-119451948-A | Pyridone compounds as TRPA1 inhibitors | D·E·萧尔研究有限责任公司 | 2025-02-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250270198-A1 | PYRIDONE COMPOUNDS AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV6 | AURKA 676/4885AURKB 896/4885INCENP 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.