Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1339128 | 1.00 | HTT (0.38) | HTTNPSR1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL3140076 | 0.90 | MOK (0.38) | HTTKDM4EALDH1A1MAPTTNKS2 | |
| Hydrochloric Acid SCHEMBL1340198 | 0.90 | MOK (0.38) | HTTKDM4EALDH1A1MAPTTNKS2 | |
| Hydrochloric Acid SCHEMBL1337067 | 0.86 | AR (0.37) | HTTNPSR1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL3130489 | 0.85 | AR (0.37) | HTTNPSR1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL1338183 | 0.83 | NR5A2 (0.43) | HTTNPSR1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL1338233 | 0.82 | GABRA1 (0.37) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| Hydrochloric Acid SCHEMBL1339640 | 0.82 | ALPL (0.36) | CYP3A4KDM4EALDH1A1SRCKMT2A | |
| Hydrochloric Acid SCHEMBL1338816 | 0.82 | MCHR1 (0.37) | CYP3A4CNR2CYP2C19 | |
| SCHEMBL3260114 | 0.82 | ALPL (0.36) | CYP3A4KDM4EALDH1A1SRCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |