Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOK | Q9UQ07 | 4/20 | 0.38 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.36 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.36 |
| ▸ | ARF6 | P62330 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1340198 | 1.00 | MOK (0.38) | MOKCYP2A13SLC2A2ARF6MAPT | |
| SCHEMBL3139962 | 0.92 | MCHR1 (0.37) | CNR1CNR2KCNH2 | |
| Hydrochloric Acid SCHEMBL1338816 | 0.92 | MCHR1 (0.37) | CNR1CNR2KCNH2 | |
| Hydrochloric Acid SCHEMBL1339640 | 0.92 | ALPL (0.36) | KDM4EALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL3260114 | 0.92 | ALPL (0.36) | KDM4EALDH1A1SMN1; SMN2KCNH2 | |
| Hydrochloric Acid SCHEMBL1339128 | 0.90 | HTT (0.38) | MAPTMAPK1HTTCNR2KDM4E | |
| SCHEMBL3140152 | 0.90 | HTT (0.38) | MAPTMAPK1HTTCNR2KDM4E | |
| SCHEMBL1338233 | 0.85 | GABRA1 (0.37) | CNR1CNR2KDM4EALDH1A1KCNH2 | |
| SCHEMBL1339358 | 0.85 | CNR1 (0.38) | CNR1CNR2KDM4EALDH1A1 | |
| SCHEMBL1338183 | 0.85 | NR5A2 (0.43) | MAPTMAPK1HTTTP53ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |