SCHEMBL31411458

SCHEMBL31411458

C[Si](C)(C)CCOCn1nc(C=O)c2c(F)cccc21

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F2RL1 P55085 1/20 0.35
DGAT1 O75907 3/20 0.35
PTGER4 P35408 1/20 0.34
NPC1 O15118 1/20 0.33
ALOX5AP P20292 2/20 0.32
FEN1 P39748 2/20 0.32
RORC P51449 2/20 0.32
P2RX7 Q99572 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31411385 0.88 F2RL1 (0.35) F2RL1DGAT1NPC1ALOX5APFEN1
SCHEMBL25250578 0.85 EGFR (0.35) DGAT1NPC1
SCHEMBL30566004 0.85 EGFR (0.35) DGAT1NPC1
SCHEMBL31411406 0.84 F2RL1 (0.32) F2RL1DGAT1NPC1
SCHEMBL31460042 0.81 DGAT1 (0.36) F2RL1DGAT1NPC1ALOX5APFEN1
SCHEMBL700961 0.81 TRPA1 (0.35) F2RL1DGAT1NPC1P2RX7
SCHEMBL6493626 0.81 SCN9A (0.33) DGAT1NPC1
SCHEMBL29396507 0.80 NPC1 (0.42) DGAT1PTGER4NPC1
SCHEMBL14735600 0.80 NPC1 (0.42) DGAT1PTGER4NPC1
SCHEMBL6386596 0.79 HTR2C (0.33) DGAT1NPC1ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735425-A1 COMPOUNDS Psylo Pty Ltd (AU) 2026-05-06 EP disclosed
US-20250353818-A1 Compounds Psylo Pty Ltd (AU) 2025-11-20 US disclosed
US-12428380-B2 Compounds Psylo Pty Ltd (AU) 2025-09-30 US disclosed
US-20250214943-A1 Compounds Psylo Pty Ltd (AU) 2025-07-03 US disclosed
WO-2025000053-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-01-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214943-A1 Compounds NLN, SLC18A2, PYGB F2RL1 4296/4885DGAT1 1102/4885PTGER4 2076/4885
US-12428380-B2 Compounds NLN, SLC18A2, PYGB F2RL1 4296/4885DGAT1 1102/4885PTGER4 2076/4885
US-20250353818-A1 Compounds NLN, SLC18A2, PYGB F2RL1 4296/4885DGAT1 1102/4885PTGER4 2076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.