Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 3/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8252700 | 0.84 | MMP13 (0.51) | MMP13HPGDSACKR3SLC6A4PDE4B | |
| SCHEMBL8252142 | 0.82 | MMP13 (0.49) | MMP13ACKR3SLC6A4PDE4BGPR119 | |
| SCHEMBL7099217 | 0.81 | GPR119 (0.51) | MMP13HPGDSGPR119KDM4EMAPT | |
| SCHEMBL9196150 | 0.80 | MEN1 (0.45) | MMP13ACKR3DRD2SLC6A4PDE4B | |
| SCHEMBL1280710 | 0.79 | ACKR3 (0.46) | MMP13HPGDSACKR3DRD2SLC6A4 | |
| SCHEMBL11877235 | 0.79 | DRD2 (0.60) | DRD2SLC6A4KDM4EMAPT | |
| SCHEMBL25238399 | 0.79 | NAMPT (0.56) | MMP13HPGDSGPR119KDM4EMAPT | |
| SCHEMBL30456397 | 0.79 | NAMPT (0.56) | MMP13HPGDSGPR119KDM4EMAPT | |
| SCHEMBL25274350 | 0.79 | GPR119 (0.52) | HPGDSGPR119KDM4EMAPTTHRB | |
| SCHEMBL1862245 | 0.78 | KDM2B (0.59) | MMP13HPGDSACKR3MAPTUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025045746-A1 | PYRAZOLE DERIVATIVES AS SARM1 INHIBITORS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2025-03-06 | — | — | WO | disclosed |