Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL635694 | 0.84 | SRC (0.54) | ALDH1A1POLBMAPTSRCERN1 | |
| SCHEMBL27620236 | 0.82 | TUBB1 (0.46) | TUBB1ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL31474876 | 0.81 | ALDH1A1 (0.56) | ALDH1A1POLBMAPTKMT2AABCG2 | |
| SCHEMBL269268 | 0.81 | ALDH1A1 (0.56) | ALDH1A1POLBMAPTKMT2AABCG2 | |
| Alcohol SCHEMBL28299718 | 0.77 | ABCG2 (0.51) | TUBB1ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL8032642 | 0.76 | BCHE (0.50) | TUBB1KMT2AERN1L3MBTL1KDM4E | |
| SCHEMBL8506220 | 0.76 | ERN1 (0.46) | TUBB1ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL6753702 | 0.76 | ALDH1A1 (0.43) | TUBB1ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL29729025 | 0.75 | CA1 (0.59) | ALDH1A1POLBMAPTKMT2AABCG2 | |
| SCHEMBL3345839 | 0.75 | CA1 (0.59) | ALDH1A1POLBMAPTKMT2AABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | disclosed |