Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327164 | 0.95 | ERN1 (0.44) | ALDH1A1SRCTUBB1L3MBTL1TSHR | |
| SCHEMBL4520879 | 0.85 | ALDH1A1 (0.40) | ALDH1A1SRCTUBB1L3MBTL1TSHR | |
| SCHEMBL3213856 | 0.85 | SRC (0.56) | ALDH1A1SRCL3MBTL1TSHRNPC1 | |
| SCHEMBL16096242 | 0.80 | TUBB1 (0.35) | ALDH1A1SRCTUBB1L3MBTL1TSHR | |
| SCHEMBL31359164 | 0.80 | LMNA (0.36) | ALDH1A1SRCTUBB1L3MBTL1FDPS | |
| SCHEMBL8506220 | 0.79 | ERN1 (0.46) | ALDH1A1SRCTUBB1L3MBTL1NPC1 | |
| SCHEMBL27620236 | 0.79 | TUBB1 (0.46) | ALDH1A1SRCTUBB1L3MBTL1ERN1 | |
| SCHEMBL31359218 | 0.79 | TUBB1 (0.40) | ALDH1A1SRCTUBB1L3MBTL1TSHR | |
| SCHEMBL3599750 | 0.78 | ERN1 (0.37) | ALDH1A1SRCTUBB1L3MBTL1TSHR | |
| SCHEMBL22230878 | 0.78 | CA1 (0.41) | ALDH1A1SRCTUBB1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283672-B1 | ANTITUBULIN ASSEMBLY AND CELL GROWTH INHIBITOR DENOMINATED \"DIOXOSTATIN\ | UNIV ARIZONA STATE (US) | 2004-11-17 | — | — | EP | disclosed |
| US-20040122083-A1 | Antitubulin assembly and cell growth inhibitor denominated \"dioxostatin\ | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2004-06-24 | — | — | US | disclosed |
| EP-1283672-A1 | ANTITUBULIN ASSEMBLY AND CELL GROWTH INHIBITOR DENOMINATED \"DIOXOSTATIN\ | Arizona Board of Regents, acting for and on behalf of Arizona State University (US) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001084929-A1 | ANTITUBULIN ASSEMBLY AND CELL GROWTH INHIBITOR DENOMINATED 'DIOXOSTATIN' | ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122083-A1 | Antitubulin assembly and cell growth inhibitor denominated \"dioxostatin\ | MCL1, TUBA1C, TUBB8 | ALDH1A1 3797/4885SRC 2361/4885TUBB1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.