Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127418 | 1.00 | SIGMAR1 (0.43) | SIGMAR1GRIN1GRIN2BDPP4DRD2 | |
| SCHEMBL3138000 | 1.00 | SIGMAR1 (0.43) | SIGMAR1GRIN1GRIN2BDPP4DRD2 | |
| SCHEMBL3137694 | 1.00 | SIGMAR1 (0.43) | SIGMAR1GRIN1GRIN2BDPP4DRD2 | |
| SCHEMBL3137699 | 1.00 | SIGMAR1 (0.43) | SIGMAR1GRIN1GRIN2BDPP4DRD2 | |
| SCHEMBL13270119 | 0.97 | SIGMAR1 (0.43) | SIGMAR1GRIN1GRIN2BDPP4DRD2 | |
| SCHEMBL3136874 | 0.93 | SIGMAR1 (0.48) | SIGMAR1GRIN1GRIN2BDPP4DRD2 | |
| SCHEMBL13268688 | 0.93 | SIGMAR1 (0.48) | SIGMAR1GRIN1GRIN2BDPP4DRD2 | |
| SCHEMBL3136449 | 0.81 | DRD2 (0.48) | SIGMAR1DPP4DRD2ACHEDRD3 | |
| SCHEMBL3136453 | 0.81 | DRD2 (0.48) | SIGMAR1DPP4DRD2ACHEDRD3 | |
| SCHEMBL3133653 | 0.80 | ALDH1A1 (0.46) | SIGMAR1DRD2HTR2AHTR2CCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399445-B9 | SUBSTITUTED PYRROLOQUINOLINES AND PYRIDOQUINOLINES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |
| EP-1399445-B9 | SUBSTITUTED PYRROLOQUINOLINES AND PYRIDOQUINOLINES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |
| EP-1399445-B1 | SUBSTITUTED PYRROLOQUINOLINES AND PYRIDOQUINOLINES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1399445-B1 | SUBSTITUTED PYRROLOQUINOLINES AND PYRIDOQUINOLINES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-08-05 | — | — | EP | disclosed |