SCHEMBL31420241

SCHEMBL31420241

Cc1n[nH]c(C)c1-c1ccc2sc(NC(=O)[C@@H]3CCN(C#N)C3)nc2c1

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ UCHL1 P09936 3/20 0.47
▸ ABL1 P00519 2/20 0.47
▸ USP30 Q70CQ3 10/20 0.46
▸ ADORA2A P29274 1/20 0.45
▸ MAP4K1 Q92918 2/20 0.44
▸ ROCK2 O75116 1/20 0.41
▸ OTUD7B Q6GQQ9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31420247 1.00 UCHL1 (0.47) UCHL1ABL1USP30ADORA2AMAP4K1
SCHEMBL17632722 0.93 MAP4K1 (0.52) UCHL1ABL1USP30MAP4K1
SCHEMBL17632727 0.93 MAP4K1 (0.52) UCHL1ABL1USP30MAP4K1
SCHEMBL17632022 0.86 USP30 (0.51) UCHL1USP30
SCHEMBL31166693 0.86 USP30 (0.51) UCHL1USP30
SCHEMBL31420223 0.82 UCHL1 (0.47) UCHL1USP30MAP4K1OTUD7B
SCHEMBL31420255 0.82 ABL1 (0.48) ABL1USP30ADORA2AMAP4K1ROCK2
SCHEMBL31420310 0.82 ABL1 (0.48) ABL1USP30ADORA2AMAP4K1ROCK2
SCHEMBL31420243 0.81 ABL1 (0.52) ABL1ADORA2AMAP4K1ROCK2
SCHEMBL31420215 0.81 ABL1 (0.52) ABL1ADORA2AMAP4K1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119528901-B Thiazole compound, dessumo and/or deubiquitinase inhibitor, and preparation methods and applications thereof Shanghai tongji hospital (CN) 2026-05-26 — — CN disclosed
CN-119528901-A Thiazole compound, dessumo and/or deubiquitinase inhibitor, and preparation methods and applications thereof 上海市同济医院 2025-02-28 — — CN disclosed
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