Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.32 |
| ▸ | GLRB | P48167 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2308100 | 0.85 | CES2 (0.42) | KDM4EAGBL2MRGPRX4 | |
| SCHEMBL3141709 | 0.84 | ESR1 (0.33) | PGRESR1ESR2 | |
| SCHEMBL4234700 | 0.84 | ESR1 (0.33) | PGRESR1ESR2 | |
| SCHEMBL3136915 | 0.81 | NOTUM (0.41) | KDM4EMRGPRX4 | |
| SCHEMBL3140737 | 0.79 | CYP3A4 (0.44) | KDM4EL3MBTL1AGBL2GLRA3GLRB | |
| SCHEMBL2313613 | 0.76 | KDM4E (0.45) | KDM4EL3MBTL1AGBL2MRGPRX4 | |
| SCHEMBL424607 | 0.75 | POLQ (0.40) | MRGPRX4 | |
| SCHEMBL1275830 | 0.75 | HTT (0.42) | PGRESR1ESR2 | |
| SCHEMBL3146082 | 0.75 | ESR1 (0.33) | PGRESR1ESR2 | |
| SCHEMBL16150471 | 0.74 | SMN1; SMN2 (0.39) | KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466180-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2013-06-18 | — | — | US | disclosed |
| US-20100076078-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CORP PROTECTION, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| CN-101578260-A | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2009-11-11 | — | — | CN | disclosed |
| EP-2069287-A1 | INSECTICIDAL COMPOUNDS | Syngeta Participations AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008031534-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076078-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, CHRM2 | PTPN1 3208/4885PTPN11 4265/4885METAP2 3916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.