Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32660011 | 0.82 | HCAR3 (0.67) | HCAR3HDAC8MEN1KMT2ACREBBP | |
| SCHEMBL32660050 | 0.82 | HCAR3 (0.67) | HCAR3HDAC8MEN1KMT2ACREBBP | |
| SCHEMBL2432136 | 0.80 | ALOX15 (0.57) | NPC1RAB9AMEN1KMT2APDE5A | |
| SCHEMBL2428969 | 0.80 | ALOX15 (0.64) | NPC1RAB9AHDAC8MEN1KMT2A | |
| SCHEMBL22097712 | 0.80 | HCAR3 (0.59) | HCAR3HDAC8MEN1KMT2ACREBBP | |
| SCHEMBL2428992 | 0.79 | DRD2 (0.44) | HCAR3KMT2AL3MBTL1ALDH1A1HPGD | |
| SCHEMBL2428995 | 0.79 | DRD2 (0.44) | HCAR3KMT2AL3MBTL1ALDH1A1HPGD | |
| SCHEMBL22097616 | 0.78 | HCAR3 (0.61) | HCAR3HDAC8MEN1KMT2ACREBBP | |
| SCHEMBL14292084 | 0.77 | MEN1 (0.47) | MEN1KMT2AL3MBTL1LMNAALOX15 | |
| SCHEMBL22093103 | 0.77 | MEN1 (0.47) | NPC1RAB9AMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-B1 | TROPANE COMPOUNDS | EXELIXIS INC (US) | 2010-03-03 | — | — | EP | disclosed |