Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 5/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3780122 | 0.99 | CHRNB2 (0.40) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3263859 | 0.89 | S1PR1 (0.39) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3150638 | 0.88 | CYP11B1 (0.47) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3147286 | 0.87 | CYP11B1 (0.46) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3143079 | 0.86 | CHRNB2 (0.51) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3137048 | 0.85 | CYP11B2 (0.40) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3147299 | 0.85 | INPPL1 (0.40) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3770692 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3768488 | 0.84 | INPPL1 (0.40) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3773098 | 0.84 | CYP11B2 (0.39) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |