Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 3/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3768488 | 0.99 | INPPL1 (0.40) | INPPL1PRMT5WDR77CDC7PLK4 | |
| SCHEMBL3137026 | 0.87 | INPPL1 (0.38) | INPPL1CHEK1AKT1CHRNB2CHRNB1 | |
| SCHEMBL3143079 | 0.86 | CHRNB2 (0.51) | AXLMKNK2CHRNB2CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL3770803 | 0.86 | INPPL1 (0.38) | INPPL1CHEK1AKT1CHRNB2CHRNB1 | |
| SCHEMBL3145265 | 0.86 | CHRNB2 (0.47) | INPPL1PRMT5WDR77AKT1CHRNB2 | |
| SCHEMBL3142728 | 0.85 | CHRNB2 (0.40) | CDC7DAPK3DYRK3RPS6KA5PRKD3 | |
| SCHEMBL3150638 | 0.85 | CYP11B1 (0.47) | PRMT5WDR77CHRNB2CHRNB1CHRNB4 | |
| SCHEMBL3137048 | 0.85 | CYP11B2 (0.40) | PRMT5WDR77CDC7DAPK3DYRK3 | |
| Hydrochloric Acid SCHEMBL3770692 | 0.85 | CHRNB2 (0.50) | AXLMKNK2CHRNB2CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL3146592 | 0.85 | CHRNB2 (0.46) | INPPL1PRMT5WDR77AKT1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |