SCHEMBL31429068

SCHEMBL31429068

FC(F)(F)c1ccccc1-c1nnc(S)[nH]1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 6/20 0.45
NOTUM Q6P988 2/20 0.42
PARP1 P09874 1/20 0.41
NPY5R Q15761 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
PTGES O14684 1/20 0.38
KIF11 P52732 1/20 0.38
TRPA1 O75762 2/20 0.37
C1R P00736 1/20 0.37
TRPM8 Q7Z2W7 1/20 0.37
PSMB8 P28062 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31429224 0.77 ALDH1A1 (0.47) NOTUMPARP1PTGES
SCHEMBL31429147 0.76 TRPV1 (0.42) NPY5R
SCHEMBL26691070 0.73 IDO1 (0.46)
SCHEMBL14424585 0.73 ALDH1A1 (0.47) NOTUMNPY5RKIF11
SCHEMBL31429132 0.73 ALDH1A1 (0.47) NOTUMNPY5RKIF11
SCHEMBL10100721 0.73 ALDH1A1 (0.44) HSD11B1PTGESC1R
SCHEMBL31429099 0.73 NPC1 (0.47) HSD11B1NOTUMPARP1PTGES
SCHEMBL2755233 0.70 HTR2C (0.52) TRPA1
SCHEMBL723099 0.70 HSD11B1 (0.46) HSD11B1NOTUMPARP1NPY5RTRPA1
SCHEMBL1444981 0.70 NOTUM (0.47) HSD11B1NOTUMPARP1NPY5RTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119350258-A Perilla alcohol-1, 2, 4-triazole thioether derivative, and preparation method and application thereof 南宁师范大学 2025-01-24 CN disclosed