Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813224 | 0.85 | MPL (0.43) | HSD11B1NOTUMTRPA1KCNN4 | |
| SCHEMBL5810382 | 0.83 | NOTUM (0.49) | HSD11B1NOTUMTRPA1TRPM8TRPV1 | |
| SCHEMBL5814882 | 0.83 | HSD11B1 (0.35) | HSD11B1NOTUMTRPA1TRPM8TRPV1 | |
| SCHEMBL10211435 | 0.82 | TRPA1 (0.41) | HSD11B1TRPA1 | |
| SCHEMBL7211244 | 0.81 | NOTUM (0.39) | HSD11B1NOTUMTRPA1TRPM8TRPV1 | |
| SCHEMBL12615990 | 0.80 | ALDH1A1 (0.38) | — | |
| SCHEMBL12496574 | 0.79 | TRPA1 (0.37) | HSD11B1NOTUMTRPA1TRPM8TRPV1 | |
| SCHEMBL3574262 | 0.77 | GAA (0.58) | TRPA1 | |
| SCHEMBL8326262 | 0.76 | IDO1 (0.39) | — | |
| SCHEMBL1773738 | 0.76 | DCUN1D1 (0.47) | NOTUMTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797690-B1 | PRINTED CIRCUIT BOARD MANUFACTURE | ALPHA FRY LTD (GB) | 1999-08-11 | — | — | EP | claimed |
| US-9730321-B2 | Silver plating in electronics manufacture | CITIBANK, N.A. | 2017-08-08 | — | — | US | disclosed |
| US-20150257264-A1 | SILVER PLATING IN ELECTRONICS MANUFACTURE | ENTHONE INC. (US) | 2015-09-10 | — | — | US | disclosed |
| US-9072203-B2 | Solderability enhancement by silver immersion printed circuit board manufacture | ENTHONE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-8986434-B2 | Silver plating in electronics manufacture | ENTHONE INC. (US) | 2015-03-24 | — | — | US | disclosed |
| CN-103724335-A | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK & CO INC | 2014-04-16 | — | — | CN | disclosed |
| EP-1732904-B1 | DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | disclosed |
| CN-101663033-B | Triazole derivatives which are SMO antagonists | MERCK SHARP & DOHME | 2013-01-16 | — | — | CN | disclosed |
| US-8349393-B2 | Silver plating in electronics manufacture | ENTHONE INC. (US) | 2013-01-08 | — | — | US | disclosed |
| EP-1940393-B1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2012-07-25 | — | — | EP | disclosed |
| US-6849636-B2 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK & CO., INC. (US) | 2005-02-01 | — | — | US | disclosed |
| WO-2004058730-A2 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058741-A1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| US-20040133011-A1 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2004-07-08 | — | — | US | disclosed |
| US-5602244-A | DINUCLEOSIDE PRECURSORS IN OLIGONUCLEOTIDE SYNTHESIS; USEFUL AS ANTISENSE INHIBITORS OF TRANSLATION | COMPETITIVE TECHNOLOGIES, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| US-5218103-A | Nucleoside thiophosphoramidites | UNIVERSITY PATENTS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0378615-A4 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | — | 1992-04-08 | — | — | EP | disclosed |
| WO-1991004983-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | UNIVERSITY PATENTS, INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| EP-0378615-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | COMPETITIVE TECHNOLOGIES INC. (US) | 1990-07-25 | — | — | EP | disclosed |
| WO-1989011486-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | UNIVERSITY PATENTS, INC. (US) | 1989-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133011-A1 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885NOTUM 203/4885TRPA1 4791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.