Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432220 | 0.86 | ALDH1A1 (0.50) | ALDH1A1MAPTMAPK1TDP1RAB9A | |
| SCHEMBL8325803 | 0.85 | PARP1 (0.40) | ALDH1A1MAPTMAPK1POLBTDP1 | |
| SCHEMBL31431606 | 0.82 | PARP1 (0.44) | ALDH1A1MAPTMAPK1POLBTDP1 | |
| SCHEMBL31661652 | 0.80 | NPSR1 (0.35) | ALDH1A1MAPK1POLBRAB9ANPC1 | |
| SCHEMBL17128362 | 0.79 | KDM4E (0.43) | ALDH1A1MAPTPOLBTDP1NPC1 | |
| SCHEMBL31431473 | 0.75 | GLA (0.36) | ALDH1A1MAPTMAPK1POLBTDP1 | |
| SCHEMBL31547658 | 0.74 | UCHL3 (0.45) | ALDH1A1MAPTRAB9ANPC1NPSR1 | |
| SCHEMBL25928125 | 0.74 | OGA (0.50) | ALDH1A1MAPTMAPK1POLBTDP1 | |
| SCHEMBL17811356 | 0.74 | BCL2L1 (0.46) | — | |
| SCHEMBL20548134 | 0.74 | HSD11B1 (0.59) | MAPTRAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |