Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ESRRA | P11474 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3143352 | 0.81 | ALDH1A1 (0.35) | ATMALDH1A1ESRRAGAAHSP90AA1 | |
| SCHEMBL384122 | 0.77 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1 | |
| SCHEMBL29362042 | 0.66 | ALDH1A1 (0.73) | ATMALDH1A1ESRRAGAANR1H4 | |
| SCHEMBL35535 | 0.66 | ALDH1A1 (0.73) | ATMALDH1A1ESRRAGAANR1H4 | |
| SCHEMBL6142004 | 0.66 | ALDH1A1 (0.73) | ATMALDH1A1ESRRAGAANR1H4 | |
| SCHEMBL20548492 | 0.66 | ALDH1A1 (0.52) | ATMALDH1A1ESRRAGAANR1H4 | |
| SCHEMBL20548778 | 0.65 | ALDH1A1 (0.71) | ATMALDH1A1ESRRAGAANR1H4 | |
| SCHEMBL7204289 | 0.64 | ESRRA (0.72) | ATMALDH1A1ESRRAGAANR1H4 | |
| SCHEMBL24782527 | 0.64 | — | — | |
| SCHEMBL8986474 | 0.64 | ALDH1A1 (0.69) | ATMALDH1A1ESRRAGAANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216782-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | CHESSARI GIANNI | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216782-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | HSP90AB1, HSP90AB2P, HSP90AA1 | ATM 3272/4885ALDH1A1 2150/4885ESRRA 235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.