SCHEMBL31434010

SCHEMBL31434010

CC(C)(C)OC(=O)N1CCC(c2ccc3cn(COCC[Si](C)(C)C)nc3c2F)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.42
CNR2 P34972 1/20 0.42
ALOX5AP P20292 2/20 0.41
FEN1 P39748 2/20 0.41
NAMPT P43490 1/20 0.41
ALDH1A1 P00352 5/20 0.40
LMNA P02545 2/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HPGD P15428 4/20 0.40
KDM4E B2RXH2 3/20 0.40
MEN1 O00255 2/20 0.40
TSHR P16473 2/20 0.40
KMT2A Q03164 2/20 0.40
HSD17B10 Q99714 2/20 0.40
MAPT P10636 2/20 0.40
USP2 O75604 1/20 0.40
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31433908 0.82 GPR119 (0.41) CNR1CNR2NAMPTALDH1A1LMNA
SCHEMBL31434059 0.82 ALOX5AP (0.44) CNR1CNR2ALOX5APFEN1LMNA
SCHEMBL25306093 0.81 MAPT (0.42) CNR1NAMPTALDH1A1HPGDKDM4E
SCHEMBL20440617 0.80 HPGD (0.41) NAMPTALDH1A1HPGDKDM4EMEN1
SCHEMBL31433780 0.79 GRM1 (0.45) NAMPTGPR119
SCHEMBL30926359 0.78 SMN1; SMN2 (0.43) ALDH1A1HPGDKDM4EMEN1TSHR
SCHEMBL29319329 0.76 KDM4E (0.40) NAMPTALDH1A1LMNAHPGDKDM4E
SCHEMBL25213813 0.75 GPR119 (0.38) ALDH1A1LMNACYP2C19MEN1KMT2A
SCHEMBL29907257 0.74 SMN1; SMN2 (0.40) ALOX5APFEN1ALDH1A1LMNACYP3A4
SCHEMBL27138591 0.74 SMN1; SMN2 (0.40) ALOX5APFEN1ALDH1A1LMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050016-A1 TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS Treeline Biosciences, Inc. (US) 2025-03-06 WO disclosed