Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 5/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | MERTK | Q12866 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 3/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435599 | 0.81 | PSEN1 (0.49) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31435610 | 0.70 | KDM1A (0.35) | LRRK2NTRK1AXLCREBBP | |
| SCHEMBL5725727 | 0.69 | NPC1 (0.33) | DHODH | |
| SCHEMBL31435569 | 0.69 | SMN1; SMN2 (0.38) | AXLCREBBPJAK3RET | |
| SCHEMBL31435624 | 0.68 | RET (0.40) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31435635 | 0.65 | PIM1 (0.36) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31435588 | 0.65 | HDAC6 (0.37) | LRRK2NTRK1CREBBP | |
| SCHEMBL5725074 | 0.64 | CHRM3 (0.45) | — | |
| SCHEMBL5724839 | 0.64 | CHRM3 (0.45) | — | |
| SCHEMBL31435598 | 0.61 | PLK1 (0.36) | AXLCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119661516-A | Bicyclic heterocyclic compounds, preparation method and medical application thereof | 华润医药研究院（深圳）有限公司 | 2025-03-21 | — | — | CN | disclosed |