Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626660 | 0.83 | KCNJ1 (0.72) | KCNJ1KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4478110 | 0.82 | KCNJ1 (0.70) | KCNJ1KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL9067030 | 0.82 | KCNJ1 (0.70) | KCNJ1KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5334337 | 0.82 | KCNJ1 (0.70) | KCNJ1KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6289818 | 0.82 | KCNJ1 (0.70) | KCNJ1KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4751222 | 0.80 | SMN1; SMN2 (0.58) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL1427302 | 0.79 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL29283174 | 0.79 | ALDH1A1 (0.61) | KCNJ1KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4748942 | 0.79 | ALDH1A1 (0.61) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL17468364 | 0.79 | CXCR4 (0.55) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224170-B9 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2017-11-22 | — | — | EP | disclosed |
| EP-2157081-A1 | Indolinones substituted in six locations, their manufacture and their application as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2010-02-24 | — | — | EP | disclosed |
| EP-1224170-B1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | EP | disclosed |
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |
| EP-1224170-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027081-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |