Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247303 | 0.90 | MEN1 (0.64) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL4243486 | 0.90 | RAF1 (0.61) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL31440788 | 0.89 | KMT2A (0.61) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL5445313 | 0.89 | RAF1 (0.60) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL5456018 | 0.85 | RAF1 (0.57) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL16782003 | 0.85 | MAPT (0.70) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL8370028 | 0.85 | GRIK1 (0.65) | RAF1MEN1KMT2AMAPTLMNA | |
| SCHEMBL8368359 | 0.84 | MAPT (0.56) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL4243355 | 0.83 | MEN1 (0.55) | RAF1BRAFMEN1KMT2AMAPT | |
| SCHEMBL938321 | 0.83 | RAF1 (0.74) | RAF1BRAFMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838541-B2 | Aryl ureas with angiogenesis inhibiting activity | BAYER HEALTHCARE, LLC (US) | 2010-11-23 | — | — | US | disclosed |