Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476076 | 0.89 | RAF1 (0.61) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL4243486 | 0.89 | RAF1 (0.61) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL4247303 | 0.89 | MEN1 (0.64) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL31440788 | 0.88 | KMT2A (0.61) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL5456018 | 0.84 | RAF1 (0.57) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL16782003 | 0.84 | MAPT (0.70) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL8370028 | 0.84 | GRIK1 (0.65) | RAF1MAPTMEN1KMT2ALMNA | |
| SCHEMBL8368359 | 0.82 | MAPT (0.56) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL4243355 | 0.82 | MEN1 (0.55) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL938321 | 0.82 | RAF1 (0.74) | RAF1BRAFMAPTKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | TIE1, FLT1, FER | RAF1 11/4885BRAF 20/4885MAPT 2430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.