Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31446502 | 0.81 | PLAU (0.43) | SMN1; SMN2NPC1RAB9AGRM4LMNA | |
| SCHEMBL31445144 | 0.78 | KEAP1 (0.40) | MAPTLPAR1CYP3A4HTTTSHR | |
| SCHEMBL31445466 | 0.77 | TRPV4 (0.44) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL20241894 | 0.75 | AKR1C3 (0.41) | CYP3A4TDP1 | |
| SCHEMBL30695181 | 0.73 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL20771439 | 0.73 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL8515175 | 0.72 | KDM4E (0.50) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL18989933 | 0.72 | NAPRT (0.41) | SMN1; SMN2MAPTGRM4LMNACYP3A4 | |
| SCHEMBL31446917 | 0.72 | HSD11B1 (0.42) | — | |
| SCHEMBL20790211 | 0.71 | MEN1 (0.43) | SMN1; SMN2MAPTNPC1RAB9ALPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4642782-A2 | ALPHA-V-BETA-8 INTEGRIN INHIBITORS AND USES THEREOF | Pliant Therapeutics, Inc. (US) | 2025-11-05 | — | — | EP | disclosed |
| WO-2025072539-A1 | AMINO ACID COMPOUNDS WITH NITROGEN LINKERS AND USES THEREOF | PLIANT THERAPEUTICS, INC. (US) | 2025-04-03 | — | — | WO | disclosed |