Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 12/20 | 0.56 |
| ▸ | ILK | Q13418 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31451494 | 0.85 | APP (0.56) | APPILKKDM4ENPC1GAA | |
| SCHEMBL31451601 | 0.83 | KDM4E (0.61) | APPILKKDM4ENPC1GAA | |
| SCHEMBL31451430 | 0.80 | ALDH1A1 (0.37) | APPILKNPC1MAPTRAB9A | |
| SCHEMBL20533985 | 0.79 | APP (0.57) | APPILKKDM4ENPC1GAA | |
| SCHEMBL31451616 | 0.77 | GAA (0.47) | APPILKKDM4ENPC1GAA | |
| SCHEMBL31451689 | 0.73 | ILK (0.52) | ILKKDM4ENPC1GAAMAPT | |
| SCHEMBL2461395 | 0.72 | APP (1.00) | APPKDM4ENPC1GAAMAPT | |
| SCHEMBL4157441 | 0.72 | APP (0.72) | APPKDM4ENPC1GAAMAPT | |
| SCHEMBL31530841 | 0.70 | MAPT (0.67) | APPILKKDM4ENPC1GAA | |
| SCHEMBL13806261 | 0.69 | APP (0.63) | APPILKKDM4ENPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025054187-A1 | TGR5 ANTAGONISTS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2025-03-13 | — | — | WO | disclosed |