Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 2/20 | 0.31 |
| ▸ | FNTB | P49356 | 2/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146191 | 0.92 | MAP4K4 (0.37) | MAP4K4FFAR4CCNT1CDK9CDK2 | |
| SCHEMBL3143345 | 0.89 | CYP46A1 (0.35) | CCNT1CDK9CDK2FNTAFNTB | |
| SCHEMBL3147370 | 0.89 | ABL1 (0.36) | CLK1DYRK1AATM | |
| SCHEMBL3152381 | 0.87 | AR (0.38) | MAP4K4 | |
| SCHEMBL3770604 | 0.81 | FFAR4 (0.33) | MAP4K4FFAR4CCNT1CDK9CDK2 | |
| SCHEMBL3257000 | 0.80 | FFAR4 (0.42) | MAP4K4FFAR4 | |
| SCHEMBL3156239 | 0.79 | ALDH1A1 (0.33) | — | |
| SCHEMBL3141366 | 0.77 | SYK (0.37) | CCNT1CDK9CDK2CLK1DYRK1A | |
| SCHEMBL3151064 | 0.77 | RAF1 (0.38) | — | |
| Hydrochloric Acid SCHEMBL3778971 | 0.76 | SYK (0.36) | MAP4K4CCNT1CDK9CDK2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |