Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 5/20 | 0.32 |
| ▸ | BRAF | P15056 | 4/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145780 | 0.89 | MAP4K4 (0.34) | CLK1DYRK1AATM | |
| SCHEMBL3151064 | 0.88 | RAF1 (0.38) | RAF1BRAF | |
| SCHEMBL3147365 | 0.81 | ABL1 (0.37) | ABL1CLK1DYRK1AFYNRAF1 | |
| SCHEMBL3151465 | 0.81 | ABL1 (0.35) | ABL1 | |
| SCHEMBL3843144 | 0.80 | ABL1 (0.34) | ABL1CLK1DYRK1AFYNRAF1 | |
| SCHEMBL3147215 | 0.80 | ABL1 (0.37) | ABL1 | |
| SCHEMBL3146191 | 0.80 | MAP4K4 (0.37) | KCNH2 | |
| SCHEMBL3154907 | 0.79 | SYK (0.33) | SYKKCNH2 | |
| SCHEMBL3768495 | 0.78 | SSTR5 (0.37) | RAF1BRAFSSTR5 | |
| SCHEMBL3143345 | 0.77 | CYP46A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |