SCHEMBL31458730

SCHEMBL31458730

Cc1nn(COCC[Si](C)(C)C)cc1-c1ccn2nc(NC3CCOCC3)nc2c1N1CC2CC1C2

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.32
KLKB1 P03952 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31458737 0.84 GRM2 (0.33) JAK2KLKB1
SCHEMBL31458606 0.80 PIM1 (0.33) JAK2
SCHEMBL31458696 0.74 MAPK1 (0.33) JAK2
SCHEMBL31458577 0.71 MAPK1 (0.32)
SCHEMBL31458746 0.64 PDE1B (0.36)
SCHEMBL31458672 0.64 NUDT1 (0.37) JAK2
SCHEMBL26453018 0.58 DGAT1 (0.39) KLKB1
SCHEMBL25227147 0.58 CD274 (0.39) JAK2
SCHEMBL22143711 0.58 FFAR4 (0.36) JAK2KLKB1
SCHEMBL5270541 0.57 MEN1 (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096061-A1 CDK2 INHIBITORS AND USES THEREOF ODYSSEY THERAPEUTICS, INC. (US) 2025-05-08 WO disclosed