Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31459447 | 0.83 | HCAR3 (0.42) | ALDH1A1GAAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL2519952 | 0.83 | SMN1; SMN2 (0.47) | ALDH1A1GAASMN1; SMN2POLBNPC1 | |
| SCHEMBL31459416 | 0.83 | ALDH1A1 (0.41) | ALDH1A1GAAHPGDSMN1; SMN2POLB | |
| SCHEMBL27258465 | 0.82 | ALDH1A1 (0.44) | ALDH1A1GAAHPGDSMN1; SMN2POLB | |
| SCHEMBL19994230 | 0.82 | SMN1; SMN2 (0.48) | ALDH1A1GAAHPGDSMN1; SMN2POLB | |
| SCHEMBL18695261 | 0.81 | TP53 (0.49) | ALDH1A1GAAHPGDSMN1; SMN2POLB | |
| SCHEMBL31459316 | 0.79 | GAA (0.42) | ALDH1A1GAAHPGDPOLBSLC34A1 | |
| SCHEMBL22637864 | 0.78 | ALDH1A1 (0.42) | ALDH1A1GAAHPGDSMN1; SMN2POLB | |
| SCHEMBL31459342 | 0.76 | ALDH1A1 (0.42) | ALDH1A1GAAHPGDSMN1; SMN2POLB | |
| SCHEMBL16815462 | 0.75 | GAA (0.41) | ALDH1A1GAASMN1; SMN2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096660-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096662-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096658-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096654-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096657-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096653-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |