Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837843 | 0.76 | BACE1 (0.39) | NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL31459664 | 0.71 | HTR1D (0.44) | ACHENPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL31737438 | 0.71 | ACHE (0.43) | HDAC4ACHEHDAC3HDAC1HDAC2 | |
| SCHEMBL19290092 | 0.69 | ACHE (0.41) | HDAC4ACHENPC1RAB9APKM | |
| SCHEMBL28153560 | 0.69 | KDM4E (0.50) | ACHESMN1; SMN2 | |
| SCHEMBL28724963 | 0.69 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK14POLB | |
| SCHEMBL2087457 | 0.68 | ACHE (0.48) | HDAC4ACHEPKMSMN1; SMN2EED | |
| SCHEMBL31459659 | 0.66 | LMNA (0.42) | ACHEPKMSMN1; SMN2EED | |
| SCHEMBL22763796 | 0.66 | ACHE (0.50) | ACHEPKMSMN1; SMN2EED | |
| SCHEMBL170719 | 0.66 | ACHE (0.50) | ACHEPKMSMN1; SMN2EED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096658-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096662-A1 | COMPOSITIONS AND INHIBITORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-05-08 | — | — | WO | disclosed |