SCHEMBL3146178

SCHEMBL3146178

CC(Cc1ccccc1-c1cccc2ccccc12)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.51
APAF1 O14727 1/20 0.51
POLB P06746 1/20 0.51
MAPT P10636 1/20 0.51
RECQL P46063 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
CTNNB1 P35222 1/20 0.50
PTGER1 P34995 1/20 0.49
PTGER4 P35408 1/20 0.49
PTGER3 P43115 1/20 0.49
PTGER2 P43116 1/20 0.49
AKR1C3 P42330 1/20 0.49
AKR1C2 P52895 1/20 0.49
KMT2A Q03164 1/20 0.49
PPARG P37231 6/20 0.48
PPARA Q07869 6/20 0.48
TDP1 Q9NUW8 1/20 0.46
MMP9 P14780 1/20 0.45
MMP8 P22894 1/20 0.45
MMP14 P50281 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6907446 0.87 CTNNB1 (0.59) KDM4EAPAF1POLBMAPTRECQL
SCHEMBL25846959 0.87 CTNNB1 (0.59) KDM4EAPAF1POLBMAPTRECQL
SCHEMBL16017641 0.87 CTNNB1 (0.59) KDM4EAPAF1POLBMAPTRECQL
SCHEMBL3142514 0.85 KDM4E (0.49) KDM4EAPAF1POLBMAPTRECQL
SCHEMBL3159240 0.85 AKR1C3 (0.51) KDM4EAPAF1POLBMAPTRECQL
SCHEMBL28690577 0.84 AKR1C3 (0.59) KDM4ECTNNB1AKR1C3AKR1C2KMT2A
SCHEMBL17051298 0.82 KMT2A (0.51) KDM4EAPAF1POLBMAPTRECQL
SCHEMBL2906023 0.82 KMT2A (0.51) KDM4EMAPTRECQLCTNNB1KMT2A
SCHEMBL23189270 0.79 KMT2A (0.71) KDM4EAPAF1POLBMAPTRECQL
SCHEMBL3149585 0.79 KMT2A (0.71) KDM4EAPAF1POLBMAPTRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1270614-B1 Copolymers containing propylene and alpha-olefin comonomer BASELL POLYOLEFINE GMBH (DE) 2010-01-27 EP disclosed
US-6787618-B1 TRANSPARENT, STIFF MOLDING MATERIALS; IMPACT TOUGHNESS; FOOD PACKAGING BASELL POLYPROPYLEN GMBH (DE) 2004-09-07 US disclosed
EP-0776913-B1 High molecular weight copolymers BASELL POLYOLEFINE GMBH (DE) 2004-02-04 EP disclosed
EP-1270614-A2 Copolymers containing propylene and alpha-olefin comonomer Basell Polyolefine GmbH (DE) 2003-01-02 EP disclosed
US-6255506-B1 SUPPORTED SYSTEM IN POLYMERIZATION OR COPOLYMERIZATION OF HIGH MOLECULAR WEIGHT POLYOLEFINS OF HIGH ISOTACTICITY AND NARROW MOLECULAR-WEIGHT DISTRIBUTION; FILMS, SHEETS OR LARGE HOLLOW ARTICLES OR MOLDINGS TARGOR GMBH (DE) 2001-07-03 US disclosed
US-6242544-B1 POLYOLEFINS PREPARED USING SOLUBLE METALLOCENE COMPOUNDS IN COMBINATION WITH ALUMINOXANES; HIGH MOLECULAR WEIGHT AND ISOTACTICITY TARGOR GMBH (DE) 2001-06-05 US disclosed
US-6057408-A CATALYTIC ADDITION COPOLYMERIZATION OF PROPYLENE WITH ETHYLENE OR OLEFIN TARGOR GMBH (DE) 2000-05-02 US disclosed
US-6051727-A A POLYMERIZATION CATALYST FOR POLYOLEFINS OF HIGH MOLECULAR WEIGHT, OF PARTICULAR IMPORTANCE FOR THE PRODUCTION OF FILMS, SHEETS OR LARGE HOLLOW ARTICLES OR MOLDINGS SUCH AS PIPES TARGOR GMBH (DE) 2000-04-18 US disclosed
US-5840644-A OLEFIN POLYMERIZATION CATALYSTS TARGOR GMBH (DE) 1998-11-24 US disclosed
US-5786432-A POLYMERIZING OR COPOLYMERIZING OLEFIN IN PRESENCE OF TRANSITION METAL METALLOCENE CATALYST AND COCATALYST TARGOR GMBH (DE) 1998-07-28 US disclosed
US-5770753-A ADDITION POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-06-23 US disclosed
EP-0790076-A2 Catalysts containing metallocenes with arylsubstituted indenyl derivatives as ligands, process and intermediates for the preparation of these metallocenes and their use HOECHST AKTIENGESELLSCHAFT (DE) 1997-08-20 EP disclosed
EP-0776913-A2 High molecular weight copolymers HOECHST AKTIENGESELLSCHAFT (DE) 1997-06-04 EP disclosed