SCHEMBL3146256

SCHEMBL3146256

Nc1ccc(C2(c3ccc(N)cc3)c3cc(C#Cc4ccccc4)ccc3-c3ccc(C#Cc4ccccc4)cc32)cc1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.56
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
KDM4E B2RXH2 1/20 0.54
LMNA P02545 1/20 0.54
OPRK1 P41145 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
GRM5 P41594 5/20 0.44
APP P05067 3/20 0.44
PDE4D Q08499 3/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
ASIC3 Q9UHC3 2/20 0.36
TLR9 Q9NR96 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2707919 0.84 PDE4D (0.43) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL3136635 0.83 MAPT (0.47) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL3155270 0.83 MAPT (0.47) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL3150217 0.83 MAPT (0.47) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL3675046 0.81 ESR1 (0.41) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL18184907 0.80 PDE4D (0.50) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL3142132 0.79 MAPT (0.44) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL3146501 0.79 MAPT (0.50) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL2709285 0.77 PDE4D (0.43) GRM5PDE4D
SCHEMBL940463 0.76 SMN1; SMN2 (0.59) MAPTMEN1KMT2AKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722842-B2 Optical film and image display device NITTO DENKO CORPORATION (JP) 2014-05-13 US disclosed
US-8218937-B2 Optical film, image display device, diethynylfluorene, and polymer thereof NITTO DENKO CORPORATION (JP) 2012-07-10 US disclosed
US-20100110554-A1 OPTICAL FILM AND IMAGE DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2010-05-06 US disclosed
US-20100003490-A1 OPTICAL FILM, IMAGE DISPLAY DEVICE, DIETHYNYLFLUORENE, AND POLYMER THEREOF NITTO DENKO CORPORATION (JP) 2010-01-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100003490-A1 OPTICAL FILM, IMAGE DISPLAY DEVICE, DIETHYNYLFLUORENE, AND POLYMER THEREOF PDCD2L, FMNL1, MACF1 MAPT 250/4885MEN1 1959/4885KMT2A 2376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.