Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27075316 | 0.98 | POLB (0.51) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL16669203 | 0.98 | POLB (0.51) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL8202013 | 0.96 | POLB (0.53) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL9881188 | 0.94 | KEAP1 (0.54) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL6037476 | 0.81 | HSP90AA1 (0.47) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL7103406 | 0.81 | KEAP1 (0.68) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL9740021 | 0.81 | KEAP1 (0.68) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL11609926 | 0.81 | KEAP1 (0.68) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL9738476 | 0.81 | KEAP1 (0.68) | POLBSMN1; SMN2KEAP1KDM4EHPGD | |
| SCHEMBL16173592 | 0.81 | KEAP1 (0.68) | POLBSMN1; SMN2KEAP1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220274985-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2022-09-01 | — | — | US | disclosed |
| EP-3990455-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-05-04 | — | — | EP | disclosed |
| CN-114269744-A | Methods for preparing Toll-like receptor modulator compounds | 吉利德科学公司 | 2022-04-01 | — | — | CN | disclosed |
| US-20210017170-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2021-01-21 | — | — | US | disclosed |
| WO-2020264081-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| US-20100076086-A1 | PROCESS FOR THE PREPARATION OF O-DESMETHYL VENLAFAXINE | Merck Development Centre Private Limited Plot 1 A/2 (IN) | 2010-03-25 | — | — | US | disclosed |
| EP-2114862-A1 | PROCESS FOR THE PREPARATION OF O-DESMETHYL VENLAFAXINE | Merck Generics (UK) Limited (GB) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008093142-A1 | PROCESS FOR THE PREPARATION OF O-DESMETHYL VENLAFAXINE | GENERICS [UK] LIMITED (GB) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274985-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | TLR4, TLR3, TLR6 | POLB 2605/4885SMN1; SMN2 3233/4885KEAP1 840/4885 |
| US-20210017170-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | TLR4, TLR3, TLR6 | POLB 2605/4885SMN1; SMN2 3233/4885KEAP1 840/4885 |
| US-20100076086-A1 | PROCESS FOR THE PREPARATION OF O-DESMETHYL VENLAFAXINE | COMT, CYP3A5, MAOB | POLB 671/4885SMN1; SMN2 2377/4885KEAP1 3613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.