Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.45 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 10/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL3233236 | 0.86 | SLC13A5 (0.48) | SLC13A5MAPTALDH1A1KDM4ELMNA | |
| Glycolic Acid SCHEMBL20271336 | 0.80 | MTNR1A (0.46) | MAPTALDH1A1LMNAMEN1CYP1A2 | |
| Succinic Acid SCHEMBL27952316 | 0.80 | FFAR1 (0.51) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| Propionic Acid SCHEMBL25282288 | 0.78 | MTNR1A (0.47) | MAPTALDH1A1LMNAMEN1CYP1A2 | |
| Citric Acid SCHEMBL8430859 | 0.78 | ALDH1A1 (0.50) | SLC13A5MAPTALDH1A1KDM4ELMNA | |
| Acetic Acid SCHEMBL27465373 | 0.77 | MTNR1A (0.53) | ALDH1A1LMNAMEN1CYP1A2KMT2A | |
| SCHEMBL15709 | 0.77 | LMNA (0.52) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| SCHEMBL167127 | 0.77 | LMNA (0.52) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| Benzene SCHEMBL28097669 | 0.77 | LMNA (0.52) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| Citric Acid SCHEMBL3233225 | 0.77 | KDM4E (0.47) | SLC13A5MAPTALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101553283-B | Concentrated surfactant compositions | UNILEVER NV | 2013-12-11 | — | — | CN | disclosed |
| EP-2089111-B2 | PROCESS FOR MANUFACTURING CONCENTRATED SURFACTANT COMPOSITIONS | UNILEVER PLC (GB) | 2013-09-04 | — | — | EP | disclosed |
| EP-2089111-B1 | PROCESS FOR MANUFACTURING CONCENTRATED SURFACTANT COMPOSITIONS | UNILEVER PLC (GB) | 2010-02-24 | — | — | EP | disclosed |
| CN-101553283-A | Concentrated surfactant compositions | UNILEVER PLC (NL) | 2009-10-07 | — | — | CN | disclosed |
| EP-2089111-A1 | CONCENTRATED SURFACTANT COMPOSITIONS | Unilever PLC (GB) | 2009-08-19 | — | — | EP | disclosed |
| US-20080139434-A1 | Concentrated surfactant compositions | CONOPCO INC, D/B/A UNILEVER | 2008-06-12 | — | — | US | disclosed |
| WO-2008068222-A1 | CONCENTRATED SURFACTANT COMPOSITIONS | UNILEVER PLC (GB) | 2008-06-12 | — | — | WO | disclosed |