Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 13/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15597733 | 0.84 | GAA (0.58) | GAAKMT2ALMNAPKMPOLB | |
| SCHEMBL3158438 | 0.83 | GAA (0.61) | GAAKMT2ARAB9ANPC1POLB | |
| SCHEMBL15597703 | 0.80 | GAA (0.69) | GAAKMT2ALMNAPKMPOLB | |
| SCHEMBL28019770 | 0.79 | GAA (0.55) | GAAKMT2ALMNAPKMRAB9A | |
| SCHEMBL15597906 | 0.78 | GAA (0.53) | GAAKMT2ALMNAPKMRAB9A | |
| SCHEMBL10474111 | 0.76 | GAA (0.53) | GAAKMT2ALMNAPKMRAB9A | |
| SCHEMBL13806891 | 0.76 | GAA (0.68) | GAAKMT2ALMNAPKMPOLB | |
| SCHEMBL10296668 | 0.76 | HTT (0.63) | GAAKMT2ALMNARAB9ANPC1 | |
| SCHEMBL735325 | 0.76 | CYP1A2 (0.51) | GAAKMT2ALMNAPKMRAB9A | |
| SCHEMBL10475129 | 0.75 | GAA (0.74) | GAAKMT2ALMNAPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828182-B1 | THERAPEUTIC PYRAZOLO[3,4-B]PYRIDINES AND INDAZOLES | WARNER LAMBERT CO (US) | 2010-03-10 | — | — | EP | disclosed |
| US-7485636-B2 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | PFIZER INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080293715-A1 | Therapeutic Pyrazolo[3,4-b]Pyridines and Indazoles | WARNER LAMBERT COMPANY LLC (US) | 2008-11-27 | — | — | US | disclosed |
| US-7423054-B2 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | WARNER LAMBERT COMPANY LLC (US) | 2008-09-09 | — | — | US | disclosed |
| EP-1828182-A2 | THERAPEUTIC PYRAZOLO[3,4-B]PYRIDINES AND INDAZOLES | Warner-Lambert Company LLC (US) | 2007-09-05 | — | — | EP | disclosed |
| US-20060217376-A1 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | WARNER-LAMBERT COMPANY LLC | 2006-09-28 | — | — | US | disclosed |
| WO-2006056873-A2 | THERAPEUTIC PYRAZOLO[3,4-B] PYRIDINES AND INDAZOLES | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-01 | — | — | WO | disclosed |
| US-20060116376-A1 | Therapeutic pyrazolo[3,4-B]pyridines and indazoles | WARNER-LAMBERT COMPANY LLC | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293715-A1 | Therapeutic Pyrazolo[3,4-b]Pyridines and Indazoles | P2RX3, P2RX4, ACHE | GAA 1579/4885KMT2A 3451/4885LMNA 4535/4885 |
| US-20060116376-A1 | Therapeutic pyrazolo[3,4-B]pyridines and indazoles | P2RX3, P2RX4, ACHE | GAA 1579/4885KMT2A 3451/4885LMNA 4535/4885 |
| US-20060217376-A1 | Therapeutic pyrazolo[3,4-b]pyridines and indazoles | P2RX3, P2RX4, ACHE | GAA 1579/4885KMT2A 3451/4885LMNA 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.