Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314657 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL314659 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL11049649 | 0.86 | MAPT (0.59) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL29961863 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL21315653 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL21315644 | 0.83 | MEN1 (0.54) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL11023968 | 0.82 | TDP1 (0.45) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL4305240 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL9499752 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL10098574 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2AKR1C3AKR1C2AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966211-B1 | TRIAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | disclosed |
| US-8093240-B2 | Triazole derivatives | MERCK PATENT GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| EP-2322527-A1 | Triazole derivatives | Merck Patent GmbH (DE) | 2011-05-18 | — | — | EP | disclosed |
| US-20080306042-A1 | Triazole Derivatives | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306042-A1 | Triazole Derivatives | TGFBR1, TGFBR2, SMAD3 | SMN1; SMN2 4841/4885AKR1C3 2784/4885AKR1C2 2727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.