Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3774047 | 0.99 | CHRNB2 (0.41) | CHRNB2CHRNA4DHFRHRH1TDO2 | |
| Hydrochloric Acid SCHEMBL3770716 | 0.99 | CHRNB2 (0.41) | CHRNB2CHRNA4DHFRHRH1TDO2 | |
| SCHEMBL3145347 | 0.89 | DHFR (0.37) | DHFRHRH1TDO2ADORA2AADORA1 | |
| SCHEMBL3155932 | 0.88 | DHFR (0.39) | DHFRHRH1TDO2ADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL3773421 | 0.88 | DHFR (0.36) | DHFRHRH1TDO2ADORA2AADORA1 | |
| SCHEMBL3155137 | 0.87 | MAP4K4 (0.35) | CHRNB2 | |
| Hydrochloric Acid SCHEMBL3767963 | 0.87 | DHFR (0.38) | DHFRHRH1TDO2ADORA2AADORA1 | |
| SCHEMBL3143008 | 0.87 | CHRNB4 (0.39) | BACE1KCNH2KDM1A | |
| Hydrochloric Acid SCHEMBL3770439 | 0.86 | MAP4K4 (0.35) | CHRNB2 | |
| Hydrochloric Acid SCHEMBL3773488 | 0.86 | CHRNB4 (0.39) | BACE1KCNH2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |