Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31468773 | 0.82 | DHODH (0.38) | CYP19A1CYP11B1CYP11B2ALDH1A1ROCK2 | |
| SCHEMBL29449526 | 0.81 | PTPRC (0.52) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL679942 | 0.81 | PTPRC (0.52) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL31468774 | 0.81 | NUDT1 (0.35) | ALDH1A1KDM4EMAPTPOLBCYP1A2 | |
| SCHEMBL2648687 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HIF1ACA1CA2CA7 | |
| SCHEMBL31468775 | 0.79 | ALDH1A1 (0.38) | ALDH1A1HIF1ACA1CA2CA7 | |
| SCHEMBL4534621 | 0.77 | MAPK14 (0.49) | ALDH1A1ROCK2KDM4EGAAMAPT | |
| SCHEMBL4328683 | 0.77 | HSD17B10 (0.47) | ALDH1A1HIF1AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL31468768 | 0.76 | LOXL2 (0.38) | ROCK2GAAPOLBCYP1A2 | |
| SCHEMBL19946068 | 0.76 | KCNH2 (0.42) | CYP11B2ROCK2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025060978-A1 | TRICYCLIC PYRIDINE COMPOUND ACTING AS SARM1 ENZYME ACTIVITY INHIBITOR, AND USE THEREOF | 科辉智药(深圳)新药研究中心有限公司 | 2025-03-27 | — | — | WO | disclosed |
| CN-119661547-A | Tricyclic pyridine compounds as SARM1 enzyme activity inhibitors and application thereof | 科辉智药(深圳)新药研究中心有限公司 | 2025-03-21 | — | — | CN | disclosed |