Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 8/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137206 | 0.91 | FFAR4 (0.38) | MAP4K4EGLN1CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3146674 | 0.90 | CHRNB4 (0.43) | MAP4K4EGLN1CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3147209 | 0.89 | ABL1 (0.39) | EGLN1ABL1P2RX7FFAR4 | |
| SCHEMBL3150941 | 0.89 | MALT1 (0.41) | MAP4K4 | |
| SCHEMBL3141819 | 0.87 | EGLN1 (0.48) | EGLN1KCNH2 | |
| SCHEMBL3151015 | 0.85 | FFAR4 (0.40) | EGLN1CHRNB4CHRNA3CHRNA7P2RX7 | |
| SCHEMBL3147063 | 0.83 | P2RX7 (0.44) | MAP4K4EGLN1CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3155830 | 0.83 | SCN10A (0.42) | MAP4K4EGLN1CHRNB4CHRNA3CNR1 | |
| SCHEMBL3147012 | 0.83 | FFAR4 (0.44) | CHRNB4CHRNA3CHRNA7P2RX7FFAR4 | |
| SCHEMBL3137015 | 0.82 | ABL1 (0.37) | MAP4K4EGLN1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |