SCHEMBL31477252

SCHEMBL31477252

COC(=O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](NC(=O)OC(C)(C)C)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CTSK P43235 4/20 0.43
CTSS P25774 2/20 0.43
MAPT P10636 5/20 0.41
KLK5 Q9Y337 2/20 0.40
KMT2A Q03164 3/20 0.39
GABRB1 P18505 1/20 0.39
GABRB2 P47870 1/20 0.39
ATM Q13315 2/20 0.38
MEN1 O00255 2/20 0.37
ALDH1A1 P00352 2/20 0.37
RECQL P46063 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CTSL P07711 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4179331 0.90 CTSK (0.44) CTSKCTSSMAPTGABRB1GABRB2
SCHEMBL7750570 0.88 CTSK (0.43) CTSKCTSSMAPTGABRB1GABRB2
SCHEMBL7743269 0.88 CTSK (0.43) CTSKCTSSMAPTGABRB1GABRB2
SCHEMBL7747431 0.87 CTSK (0.42) CTSKCTSSMAPTGABRB1GABRB2
SCHEMBL31477520 0.86 KMT2A (0.42) KMT2AATMMEN1ALDH1A1
SCHEMBL13089877 0.85 CTSK (0.48) CTSKCTSSMAPTKLK5KMT2A
SCHEMBL9077908 0.85 CTSK (0.45) CTSKCTSSMAPTKLK5KMT2A
SCHEMBL6779105 0.81 CTSK (0.45) CTSKCTSSMAPTKLK5KMT2A
SCHEMBL6784157 0.81 CTSK (0.45) CTSKCTSSMAPTKLK5KMT2A
SCHEMBL3780925 0.81 CTSK (0.43) CTSKCTSSMAPTGABRB1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025085564-A1 LYSINE ACETYLTRANSFERASE INHIBITORS Kronos Bio, Inc. (US) 2025-04-24 WO disclosed