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SCHEMBL31479240

SCHEMBL31479240

CCN(C(=O)c1cc(F)ccc1-c1cc(C2CCN(CC3CCC(NC(=O)OC(C)(C)C)CC3)C2)cn2cncc12)C(C)C

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ KCNH2 Q12809 1/20 0.41
▸ JAK2 O60674 2/20 0.38
▸ JAK1 P23458 2/20 0.38
▸ DRD2 P14416 4/20 0.37
▸ NPY5R Q15761 4/20 0.34
▸ ACKR3 P25106 3/20 0.34
▸ PLK1 P53350 1/20 0.33
▸ HTR2A P28223 2/20 0.32
▸ DRD3 P35462 2/20 0.32
▸ KAT8 Q9H7Z6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31479634 0.91 MEN1 (0.35) MEN1KMT2AKCNH2JAK2JAK1
SCHEMBL31478988 0.89 MEN1 (0.40) MEN1KMT2AKCNH2JAK2JAK1
SCHEMBL31479610 0.88 MEN1 (0.51) MEN1KMT2AKCNH2ACKR3HTR2A
SCHEMBL31479645 0.88 MEN1 (0.51) MEN1KMT2AKCNH2ACKR3HTR2A
SCHEMBL31479857 0.87 KCNH2 (0.39) MEN1KMT2AKCNH2DRD2ACKR3
SCHEMBL31479427 0.86 MEN1 (0.42) MEN1KMT2AKCNH2DRD2NPY5R
SCHEMBL31479115 0.85 MEN1 (0.41) MEN1KMT2AKCNH2JAK2JAK1
SCHEMBL31479281 0.85 MEN1 (0.41) MEN1KMT2AKCNH2JAK2JAK1
SCHEMBL31478964 0.85 MEN1 (0.41) MEN1KMT2AKCNH2JAK2JAK1
SCHEMBL31479929 0.84 GPR119 (0.40) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067111-A1 MENIN-MLL INTERACTION INHIBITOR AND PREPARATION METHOD THEREFOR, AND APPLICATION 苏州必扬医药科技有限公司 2025-04-03 — — WO disclosed