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SCHEMBL31479645

SCHEMBL31479645

CCN(C(=O)c1cc(F)ccc1-c1cc([C@H]2CCN(CC3CCC(NS(=O)(=O)CC)CC3)C2)cn2cncc12)C(C)C

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.51
▸ KMT2A Q03164 2/20 0.51
▸ KCNH2 Q12809 1/20 0.51
▸ HTR2A P28223 2/20 0.38
▸ DRD3 P35462 2/20 0.38
▸ ACKR3 P25106 14/20 0.34
▸ HCRTR1 O43613 1/20 0.31
▸ HCRTR2 O43614 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31479610 1.00 MEN1 (0.51) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479857 0.90 KCNH2 (0.39) MEN1KMT2AKCNH2HTR2AACKR3
SCHEMBL31479807 0.88 MEN1 (0.50) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479240 0.88 MEN1 (0.41) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479389 0.88 MEN1 (0.49) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479949 0.85 MEN1 (0.53) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479413 0.85 MEN1 (0.48) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479895 0.85 KCNH2 (0.49) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479276 0.84 MEN1 (0.51) MEN1KMT2AKCNH2HTR2ADRD3
SCHEMBL31479775 0.84 MEN1 (0.51) MEN1KMT2AKCNH2HTR2ADRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067111-A1 MENIN-MLL INTERACTION INHIBITOR AND PREPARATION METHOD THEREFOR, AND APPLICATION 苏州必扬医药科技有限公司 2025-04-03 — — WO disclosed