SCHEMBL31479882

SCHEMBL31479882

CCN(C(=O)c1cc(F)ccc1-c1cc(N2CC(NCC3CCC(NC(=O)OC(C)(C)C)CC3)C2)cc2c1cnn2C)C(C)C

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KCNH2 Q12809 1/20 0.35
ENPP2 Q13822 1/20 0.33
PLK1 P53350 1/20 0.33
KAT8 Q9H7Z6 2/20 0.32
RET P07949 1/20 0.32
TRPV1 Q8NER1 1/20 0.31
DRD2 P14416 4/20 0.31
DRD3 P35462 2/20 0.31
LIPG Q9Y5X9 1/20 0.31
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
ACACB O00763 3/20 0.31
ACACA Q13085 2/20 0.31
DPP4 P27487 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31479288 0.92 ENPP2 (0.36) MEN1KMT2AKCNH2ENPP2PLK1
SCHEMBL31479079 0.90 CKS1B (0.36) MEN1KMT2AKCNH2PLK1RET
SCHEMBL31479595 0.88 MEN1 (0.44) MEN1KMT2AKCNH2TRPV1DRD3
SCHEMBL31479566 0.82 MEN1 (0.42) KDM1AMEN1KMT2AKCNH2PLK1
SCHEMBL31479568 0.80 CKS1B (0.41) MEN1KMT2AKCNH2PLK1RET
SCHEMBL31479712 0.80 MEN1 (0.44) KDM1AMEN1KMT2AKCNH2PLK1
SCHEMBL31479324 0.79 HCRTR1 (0.35) KDM1AMEN1KMT2AKCNH2TRPV1
SCHEMBL31479351 0.78 MEN1 (0.34) MEN1KMT2AKCNH2
SCHEMBL31479073 0.78 MEN1 (0.34) MEN1KMT2AKCNH2PLK1ALOX5AP
SCHEMBL31479897 0.77 HCRTR1 (0.34) MEN1KMT2AKCNH2TRPV1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067111-A1 MENIN-MLL INTERACTION INHIBITOR AND PREPARATION METHOD THEREFOR, AND APPLICATION 苏州必扬医药科技有限公司 2025-04-03 WO disclosed