SCHEMBL31483046

SCHEMBL31483046

COc1ncc(-c2ccn3nc(N)cc3c2)cc1OC(F)F

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 17/20 0.53
PIK3CG P48736 17/20 0.53
PIK3CB P42338 1/20 0.53
PIK3CA P42336 14/20 0.51
GRIN1 Q05586 2/20 0.38
GRIN2B Q13224 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483001 0.88 PIK3CG (0.63) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483065 0.85 PIK3CD (0.53) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483117 0.80 PIK3CD (0.51) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483062 0.76 PIK3CG (0.67) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483156 0.75 PIK3CG (0.71) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483057 0.75 PIK3CG (0.71) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483159 0.74 PIK3CG (0.70) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483081 0.74 PIK3CD (0.70) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483029 0.73 PIK3CA (0.52) PIK3CDPIK3CGPIK3CBPIK3CA
SCHEMBL31483021 0.72 PIK3CA (0.49) PIK3CDPIK3CGPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed